[TimeGuest]

Oprindeligt indsendt af TimeGuest

What can I else say ... but we'll crack the autistic code [1] ... it's just a matter of time.

Note:
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[1] I hvert fald for subgrupper på spektrummet ... ASD er nemlig samlet set en heterogen gruppe.

Der findes videnskabelige hovedteser, der arbejde med en vinkling af flg. områder:

1) Enzymatic disorder
2) Opoid activity
3) Amino acid disorder
4) Food allergy
5) Glucidic catabolisme
6) Vitamin deficiencies

Vinkler der i noget omfang måske - igen inden for subgrupper - kan indarbejdes i et egentlig: Neuro-Immune Dysfunction Syndrome (NIDS) - sandsynligvis induceret hos en særlig genotype af et eller flere virale patogener (vi har nogle kandidater i kikkerten).

Så er vi kommet et lille skridt videre ud af den tangent :-)

FASEB J. 2014 Feb 20.
Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism.
...
Serotonin and vitamin D have been proposed to play a role in autism; however, no causal mechanism has been established. Here, we present evidence that vitamin D hormone (calcitriol) activates the transcription of the serotonin-synthesizing gene tryptophan hydroxylase 2 (TPH2) in the brain at a vitamin D response element (VDRE) and represses the transcription of TPH1 in tissues outside the blood-brain barrier at a distinct VDRE.

http://www.ncbi.nlm.nih.gov/pubmed/24558199

Causal link found between vitamin D, serotonin synthesis and autism in new study

A new study by Rhonda Patrick, PhD and Bruce Ames, PhD of Children's Hospital Oakland Research Institute (CHORI) demonstrates the impact that Vitamin D may have on social behavior associated with Autism Spectrum Disorder (ASD). Dr. Patrick and Dr. Ames show that serotonin, oxytocin, and vasopressin, three brain hormones that affect social behavior, are all activated by vitamin D hormone. Autism, which is characterized by abnormal social behavior, has previously been linked to low levels of serotonin in the brain and to low vitamin D levels, but no mechanism has linked the two until now.

http://www.sciencedaily.com/releases...0226110836.htm